The MemorEM Device

TRFT involves the generation of electromagnetic waves in the radiofrequency (RF) range by an electromagnetic wave generator. These RF waves radiate away from emitters on the head, never to return. Transcranial Magnetic Stimulation (tMS) and Pulsed Electromagnetic Treatment (PEMT) are very different from TRFT in that both of these involve circulating magnetic fields provided by magnets. Moreover, RF waves actually consist of linked sinusoidal electric and magnetic “waves”, generating an electric field, magnetic field, and direction of wave propagation all aligned perpendicular to each other (Figure A). In the MemorEM device, such RF waves are created by a small RF wave generator worn on the arm, which is connected via wires to multiple (eight) emitters within a double-layered cap (Figure B,C). The emitters are activated sequentially at over 200 cycles per second and typically at 1 GHz when active. This unique device provides the first-ever radiofrequency treatment to the entire human forebrain since the RF waves penetrate to the center of the human brain (Figure D; a single active emitter). The device is fully self-contained and allows for near complete in-home mobility during daily 1 hour treatments, as self-administered by the subject or by the subject’s caregiver.

The MemorEM device and its bioengineered TRFT technology are secured by 9 issued U.S. patents at NeuroEM Therapeutics, Inc., which has exclusively manufactured the devices in the U.S. for clinical studies.

In small clinical studies involving up to 2½ years of TRFT to Alzheimer’s subjects, no reported or clinically-observed deleterious side effects on general health, cognitive function, or a variety of physiologic measures have occurred [Arendash et al., 2019; 2022]. Moreover, clinical safety of this radiofrequency wave technology is supported by published studies from the National Institute of Environmental Health and Safety (NIEHS), Center for Disease Control and Prevention (CDC), National Cancer Institute (NCI), and World Health Organization (WHO) [Arendash 2012; 2016].