Most of us would dearly want to live decades longer and in good health if given the opportunity − in other words, we would wish to increase our “health span” to 100 years or more. Sadly, there are no gerotherapeutic drugs that have been shown to extend human health span, although there are a number of such drugs currently being investigated. The four drugs of primary focus are methformin, nicotinamide (NAD) precursors, rapamycin, and dasatinib+quercetin. For these and other gerotherapeutics (e.g., gene therapy), no clinical trials have begun with the primary endpoint being to extend healthy human lifespan.

For any gerotherapeutic, it is highly desirable to have a single intervention to prevent/lessen many diseases of aging. Such an intervention would then automatically increase health span, resulting in a much shorter period of age-related diseases at the end of life (see Figure). Based on the current state of gerotherapeutic research, one of the most promising intervention to extend healthy longevity is not a drug or combination therein, but rather a single bioengineered device to administer a new technology to the human head – Transcranial Radiofrequency Waves.